How does the steric hindrance of 2-methoxy-2-methylpropane affect its catalytic activity?
2-Methoxy-2-methylpropane, also known as tert-butyl methyl ether (TBME), is a solvent commonly used in various organic reactions. Its steric hindrance, stemming from the bulky tert-butyl group, can influence its catalytic activity in several ways: Substrate Accessibility: The steric hindrance imposed by the tert-butyl group can limit the accessibility of reactants to the catalytic site. In